Minoxidil opens mitochondrial KATP channels and confers cardioprotection
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Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection.
Bepridil, which is clinically useful in the treatment of arrhythmias, has been reported to inhibit sarcolemmal ATP-sensitive K(+) (sarcK(ATP)) channels. However, the effect of bepridil on mitochondrial ATP-sensitive K(+) (mitoK(ATP)) channels remains unclear. The objective of the present study was to determine whether bepridil activates mitoK(ATP) channels and confers cardioprotection. SarcK(AT...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2004
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0705613